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KMID : 0604520220480040303
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 4 p.303 ~ p.312
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A Study on Inflammation and Itching of Cyperus rotundus Ethyl Acetate Fractions
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Kim Do-Gyu
Lee Ji-Yeon
Mun So-Hyun
Kim Yu-Kyung
Kim Na-Ri
Jung Ah-Reum
Jang Jun-Hwan
Lee Jae-Seob
Han Sang-Bae
Bae Jun-Tae
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Abstract
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In this study, Cyperus rotundus (C. rotundus) was fractionated into ethyl acetate to identify α-cyperone, a representative indicator, and its ethyl acetate fraction were evaluated to confirm the possibilityas a functional cosmetic ingredient. As a result of HPLC analysis, it was confirmed that the content of α-cyperone was 5.243%. In order to verify the inflammatory relief effect of the ethyl acetate fraction from C. rotundus (EAFC) and α-cyperone, it was confirmed that nitric oxide (NO) production inhibitory ability in RAW 264.7 macrophages induced an inflammatory reaction with lipopolysaccharide (LPS). Real-time qPCR analysis confirmed inhibition of mRNA expression level of inflammatory factors, IL-1β, IL-6, TNF-α, COX-2 and iNOS. As a results of conducting a clinical study using a simple cosmetic formulation containing EAFC, it was confirmed that the skin irritation stimulated by sodium lauryl sulfate (SLS) was calming and relieving itching. Through these results, it is believed that the C. rotundus can be used as a natural cosmetic ingredient that has the effect of inhibiting inflammation and relieving itching.
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KEYWORD
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Cyperus rotundus, alpha-cyperone, anti-inflammatory, nitric oxide, RAW 264.7
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